Other Glial and Glioneuronal Tumors

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Other Glial and Glioneuronal Tumors

Last updated on Saturday, February 7 2009 by jdmiles

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Glioneuronal Tumor with Neuropil Islands, medium power GFAP immunohistochemical stain
The neuropil islands stand out as GFAP nonreactive regions within an otherwise weakly GFAP positive tumor.

Glioneuronal Tumor with Neuropil Islands, synaptophysin immunohistochemical staining x 100
Synaptophysin emphasizes the sharp demarcation of these neuropil islands with adjacent less well differentiated tumor.

Glioneuronal Tumor with Neuropil Islands, synaptophysin immunohistochemical staining x 40
Synaptophysin immunohistochemical staining highlights the islands of neuropil within this see of glial cells.

Glioneuronal Tumor with Neuropil Islands, H&E stain x 40
Neuropil islands appear to float in a sea of glial cells.

Glioneuronal Tumor with Neuropil Islands, H&E stain x 200
High Magnification demonstrates both sharp demarcation of the neuropil islands, as well as advanced neuroglial differentiation within the islands compared to the surrounding tumor.

Rosetted glial neuronal tumor of the fourth ventricle, H&E x 200
Rosettes comprised of epithelioid vacuolated cells surrounding proteinaceous extracellular material, all contained within a delicate fibrillary matrix.

Rosetted glioneuronal tumor of the fourth ventricle, low power view
At low power, the tumor presents a variegated appearance with areas of microcystic and fibrillary differentiation