NeurOnc 01

Topic: Pathology

Created on Sunday, February 8 2009 by gliageek

Last modified on Sunday, February 8 2009.

 
        A) It occurs most commonly in the cerebellopontine angle and conus medullaris
 
        B) They contain abundant intracellular glycogen
 
        C) They are immunoreactive with antibodies to epithelial membrane antibodies
 
        D) It typically occurs in elderly males
 
        E) They are WHO Grade II tumors
 

 

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This question was created on February 08, 2009 by gliageek.
This question was last modified on February 08, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) It occurs most commonly in the cerebellopontine angle and conus medullaris

This answer is incorrect.

These are the most typical locations for clear cell meningiomas.  (See References)

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B) They contain abundant intracellular glycogen

This answer is incorrect.

The clear cell appearance is due to intracellular glycogen, and should not be confused with extracellular mucopolysaccharide accumulation characteristic of microcystic menigiomas  (See References)

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C) They are immunoreactive with antibodies to epithelial membrane antibodies

This answer is incorrect.

For all its shortcomings, EMA is the most reliable immunohistochemical stain in the diagnosis of meningiomas  (See References)

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D) It typically occurs in elderly males

This answer is correct.

Clear cell menigiomas are typically seen in young women  (See References)

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E) They are WHO Grade II tumors

This answer is incorrect.

Despite their bland appearance, clear cell meningiomas tend to recur and behave aggressively  (See References)

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References:

1. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia. (ISBN:0443066582)

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pathology
NeurOnc 01
Question ID: 020809062
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/08/2009
Modified: 02/08/2009
Estimated Permutations: 120