Myelin 02

Topic: Pathology

Created on Sunday, February 8 2009 by gliageek

Last modified on Sunday, February 8 2009.

 
        A) Cockayne disease
 
        B) Grinker myelinopathy (CO intoxication)
 
        C) Disseminated necrotizing leukoencephalopathy
 
        D) Pelizaeus-Merzbacher disease
 
        E) Acute disseminated encephalomyelitis
 

 

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This question was created on February 08, 2009 by gliageek.
This question was last modified on February 08, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Cockayne disease

This answer is incorrect.

Cockayne disease is characterised by perivascular SPARING of myelin, accompanied by basal ganglia calcifications and leptomeningeal fibrosis.  (See References)

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B) Grinker myelinopathy (CO intoxication)

This answer is correct.

Non-inflammatory perivascular myelin loss is characteristic of delayed carbon monoxide neurotoxicity  (See References)

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C) Disseminated necrotizing leukoencephalopathy

This answer is incorrect.

Disseminated necrotizing leukoencephalopathy affects deep white matter and brainstem tegmentum without perivascular accentuation  (See References)

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D) Pelizaeus-Merzbacher disease

This answer is incorrect.

Pelizaeus-Merzbacher disease is characterised by perivascular SPARING of myelin  (See References)

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E) Acute disseminated encephalomyelitis

This answer is incorrect.

Perivascular myelin loss defines this entity, but requires concomittant perivascular lymphocytic inflammation  (See References)

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References:

1. Graham, D.I., and Lantos, P.L. (2002). Greenfield's Neuropathology, 7th ed. Arnold Press, New York. (ISBN:0340742313)

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pathology
Myelin 02
Question ID: 020809105
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/08/2009
Modified: 02/08/2009
Estimated Permutations: 120