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Neurodegen 03

Topic: Pathology

Created on Monday, February 16 2009 by gliageek

Last modified on Monday, February 16 2009.

Courtesy of Dr. Mark Cohen

In the most common genetic form of late-onset familial Parkinson disease (LRRK2 G1920s), these alpha-synuclein positive structures are seen first in which of the following locations?

A) Anterior olfactory nucleus

B) Locus ceruleus

C) Amygdala

D) Nucleus basalis of Meynert

E) Substantia nigra

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This question was created on February 16, 2009 by gliageek.
This question was last modified on February 16, 2009.

ANSWERS AND EXPLANATIONS

A) Anterior olfactory nucleus

This answer is correct.

Correlates with hyposmia in these patients (See References)


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B) Locus ceruleus

This answer is incorrect.

Second stage (See References)


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C) Amygdala

This answer is incorrect.

Fourth stage (See References)


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D) nucleus basalis of Meynert

This answer is incorrect.

Third stage (See References)


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E) Substantia nigra

This answer is incorrect.

Third stage (See References)


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References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)

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pathology
Neurodegen 03
Question ID: 021609127
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/16/2009
Modified: 02/16/2009
Estimated Permutations: 120