Neurodegen 09

Topic: Pathology

Created on Monday, February 16 2009 by gliageek

Last modified on Monday, February 16 2009.

 
        A) Alpha-synuclein
 
        B) King's silver stain
 
        C) Paired helical filament Tau protein
 
        D) Modified Bielshowsky silver stain
 
        E) Ubiquitin
 

 

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This question was created on February 16, 2009 by gliageek.
This question was last modified on February 16, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) alpha-synuclein

This answer is correct.

The size, morphology, and H&E staining characteristics of the intracytoplasmic inclusions are those of Pick bodies, not Lewy bodies  (See References)

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B) King's silver stain

This answer is incorrect.

All silver based staining methods stain Pick bodies to a greater or lesser degree. Lewy bodies would be silver-negative.  (See References)

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C) Paired helical filament Tau protein

This answer is incorrect.

Major protein constituent of Pick bodies  (See References)

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D) Modified Bielshowsky silver stain

This answer is incorrect.

The classical way in which Pick bodies were distinguished from Lewy bodies  (See References)

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E) Ubiquitin

This answer is incorrect.

Abnormal cytoskeletal proteins are conjugated to ubiquitin  (See References)

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References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)

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pathology
Neurodegen 09
Question ID: 021609189
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/16/2009
Modified: 02/16/2009
Estimated Permutations: 120