The FrontalCortex question bank can help you study for the neurology boards.

Dementia 02

Topic: Imaging

Created on Thursday, February 22 2007 by jdmiles

Last modified on Thursday, February 22 2007.

A 69 year-old male presents to your office accompanied by his second cousin, who provides most of the history.
The second cousin states that for the past 4 years, the patient has complained of seeing visions of tiny copper doves, developed a tremor, has had trouble keeping his balance, has been having progressively worsening memory problems, has had worsening bradykinesia, and has had dramatic fluctuations in his level of arousal.
Which of the following pathology findings is MOST characteristic of this patient's disease?

 
        A) Basophilic nuclear inclusions
 
        B) Lesions in the mammillary bodies
 
        C) Inclusions comprised primarily of beta amyloid
 
        D) Inclusions comprised primarily of Huntingtin
 
        E) Inclusions comprised primarily of alpha-synuclein
 

 


Back to the question = Go back to the top of the page.
See another question like this one = Reload a different version of this question ().
Click here for a random question = Load a random question from the database.
Clone this question = Use this question as a template to create a totally NEW question.
Rate this question = Enter detailed rating for this question!
Average rating not yet available
= How users like you have rated this question.
This question was created on February 22, 2007 by jdmiles.
This question was last modified on February 22, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) basophilic nuclear inclusions

This answer is incorrect.


This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Lewy bodies are eosinophilic cytoplasmic inclusions.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this question
Average rating not yet available
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




B) lesions in the mammillary bodies

This answer is incorrect.


This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Lesions in the mammillary bodies are seen in Korsakoff amnestic state.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this question
Average rating not yet available
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




C) inclusions comprised primarily of beta amyloid

This answer is incorrect.


This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Lewy bodies are eosinophilic cytoplasmic inclusions comprised mainly of alpha-synuclein, not beta amyloid.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this question
Average rating not yet available
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




D) inclusions comprised primarily of Huntingtin

This answer is incorrect.


This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Lewy bodies are eosinophilic cytoplasmic inclusions comprised mainly of alpha-synuclein. Huntingtin is a protein associated with Huntington chorea.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this question
Average rating not yet available
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




E) inclusions comprised primarily of alpha-synuclein

This answer is correct.


This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Lewy bodies are eosinophilic cytoplasmic inclusions which contain alpha-synuclein.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this question
Average rating not yet available
Please log in if you want to rate questions.

 

 

 

 

References:

1. Victor, M., and Ropper, A.H. (2001). Adams and Victor's Principles of Neurology, 7th Edition. McGraw-Hill, New York.
2. DeKosky, S.T., Kaufer, D.I., and Lopez, O.L. (2004). The Dementias. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, 4th Edition. Butterworth Heinemann, Philadelphia. Pp. 1901-1951
3. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier, Philadelphia.
Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this question
Average rating not yet available
Please log in if you want to rate questions.

 

FrontalCortex.com -- Neurology Review Questions -- Neurology Boards -- Board Review -- Residency Inservice Training Exam -- RITE Exam Review
imaging
Dementia 02
Question ID: 02220701
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 02/22/2007
Modified: 02/22/2007
Estimated Permutations: 0

User Comments About This Question:

0 user entries
Please log in if you'd like to add a comment.