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Adverse effects of AEDs 12

Topic: Pharmacology

Created on Saturday, December 8 2007 by jdmiles

Last modified on Saturday, December 8 2007.

Which of the following is a hallmark side effect of vigabatrin?

 
        A) Aplastic anemia
 
        B) Coarsening of the facies
 
        C) Psychosis
 
        D) Hyperammonemia
 
        E) Hepatoxicity
 

 


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This question was created on December 08, 2007 by jdmiles.
This question was last modified on December 08, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) aplastic anemia

This answer is incorrect.


Aplastic anemia is a hallmark side effect of felbamate, but is less characteristic of vigabatrin.  (See References)

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B) coarsening of the facies

This answer is incorrect.


Coarsening of the facies is a hallmark side effect of phenytoin, but is less characteristic of vigabatrin.  (See References)

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C) psychosis

This answer is correct.


Side effects of vigabatrin include hyperactivity, irritability, psychosis, visual field defects, insomnia, depression, and blindness.  (See References)

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D) hyperammonemia

This answer is incorrect.


Hyperammonemia is a hallmark side effect of valproate, but is less characteristic of vigabatrin.  (See References)

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E) hepatoxicity

This answer is incorrect.


Hepatoxicity is a hallmark side effect of felbamate, but is less characteristic of vigabatrin.  (See References)

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References:

1. Greenwood, R.S. (2000). "Adverse effects of antiepileptic drugs." Epilepsia, 41 Suppl 2 S42-52. (PMID:10885739)
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pharmacology
Adverse effects of AEDs 12
Question ID: 12080712
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 12/08/2007
Modified: 12/08/2007
Estimated Permutations: 12558000

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