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the mechanisms of AED action

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Sunday, September 17 2006.

Which of the following statements regarding the mechanisms of AED action is FALSE?

 
        A) Phenobarbital has a mechanism of action which is as yet not known.
 
        B) Primidone acts as a glutamate receptor antagonist.
 
        C) Phenytoin acts as a glutamate receptor antagonist.
 
        D) Zonisamide reduces sodium currents.
 
        E) Topiramate acts as a glutamate receptor antagonist.
 

 


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This question was created on September 02, 2006 by .
This question was last modified on September 17, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Phenobarbital has a mechanism of action which is as yet not known.

This answer is incorrect.


The statement, "Phenobarbital has a mechanism of action which is as yet not known." is true.
Phenobarbital reduces sodium currents, causes an increase of GABA-mediated currents, acts as a glutamate receptor antagonist, and has a mechanism of action which is as yet not known.  (See References)

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B) Primidone acts as a glutamate receptor antagonist.

This answer is incorrect.


The statement, "Primidone acts as a glutamate receptor antagonist." is true.
Primidone reduces sodium currents, causes an increase of GABA-mediated currents, acts as a glutamate receptor antagonist, and has a mechanism of action which is as yet not known.  (See References)

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C) Phenytoin acts as a glutamate receptor antagonist.

This answer is incorrect.


The statement, "Phenytoin acts as a glutamate receptor antagonist." is true.
Phenytoin reduces sodium currents, causes an increase of GABA-mediated currents, acts as a glutamate receptor antagonist, and has a mechanism of action which is as yet not known.  (See References)

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D) Zonisamide reduces sodium currents.

This answer is incorrect.


The statement, "Zonisamide reduces sodium currents." is true.
Zonisamide reduces sodium currents, and reduces T-Calcium currents.  (See References)

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E) Topiramate acts as a glutamate receptor antagonist.

This answer is correct.


The statement, "Topiramate acts as a glutamate receptor antagonist." is false.
Topiramate reduces sodium currents, causes an increase of GABA-mediated currents, and has a mechanism of action which is as yet not known.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
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pathology
the mechanisms of AED action
Question ID: 299569689
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/17/2006
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