antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

 
        A) Carbamazepine is indicated for treatment of absence seizures.
 
        B) Primidone causes increase of GABA-mediated currents.
 
        C) Carbamazepine has been shown in comparative studies to be one of the two safest of the older AEDs.
 
        D) Carbamazepine is a known teratogen, or evidence for its teratogenicity exists.
 
        E) Lamotrigine causes increase of GABA-mediated currents.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Carbamazepine is indicated for treatment of absence seizures.

This answer is correct.

The statement, "Carbamazepine is indicated for treatment of absence seizures." is false.
Carbamazepine causes reduction of sodium currents, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily in the liver, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, is associated with an increased risk of spina bifida if taken during pregnancy, is excreted in breast milk, must be started at a low dose, may exacerbate absence seizures, has been shown in comparative studies to be one of the two safest of the older AEDs, and is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.  (See References)

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B) Primidone causes increase of GABA-mediated currents.

This answer is incorrect.

The statement, "Primidone causes increase of GABA-mediated currents." is true.
Primidone causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, and is excreted in breast milk.  (See References)

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C) Carbamazepine has been shown in comparative studies to be one of the two safest of the older AEDs.

This answer is incorrect.

The statement, "Carbamazepine has been shown in comparative studies to be one of the two safest of the older AEDs." is true.
Carbamazepine causes reduction of sodium currents, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily in the liver, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, is associated with an increased risk of spina bifida if taken during pregnancy, is excreted in breast milk, must be started at a low dose, may exacerbate absence seizures, has been shown in comparative studies to be one of the two safest of the older AEDs, and is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.  (See References)

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D) Carbamazepine is a known teratogen, or evidence for its teratogenicity exists.

This answer is incorrect.

The statement, "Carbamazepine is a known teratogen, or evidence for its teratogenicity exists." is true.
Carbamazepine causes reduction of sodium currents, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily in the liver, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, is associated with an increased risk of spina bifida if taken during pregnancy, is excreted in breast milk, must be started at a low dose, may exacerbate absence seizures, has been shown in comparative studies to be one of the two safest of the older AEDs, and is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.  (See References)

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E) Lamotrigine causes increase of GABA-mediated currents.

This answer is incorrect.

The statement, "Lamotrigine causes increase of GABA-mediated currents." is true.
Lamotrigine causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of atonic seizures, is indicated for treatment of tonic seizures, is indicated for treatment of myoclonic seizures, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily in the liver, and is excreted in breast milk.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
Estimated Permutations: 0