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Dillon MCQ 03

Topic: Anatomy

Created on Saturday, November 26 2022 by dillon

Last modified on Saturday, November 26 2022.

Botulism toxin can be used in the treatment of muscle spasms and headaches, the best description of the MOA is which of the following?

 
        A) Inhibition of acetylcholine release at the presynaptic terminals
 
        B) Causing uncontrolled Ca++ independent release of neurotransmitters
 
        C) Activation of acetylcholine release at the presynaptic terminals
 
        D) Complete inhibition of GABA release from presynaptic terminals
 

 


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This question was created on November 26, 2022 by dillon.
This question was last modified on November 26, 2022.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) inhibition of acetylcholine release at the presynaptic terminals

This answer is correct.


"The medication botulinum toxin is used for several conditions, including muscle spasm and tension headache , and works by inhibiting the release of acetylcholine from the presynaptic terminals of cholinergic neurons. Of course there are antiepileptic medications that also use this technology of inhibiting excitatory neurotransmitter release from presynaptic terminals." (Nolte, Ch. 8)  (See References)

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B) Causing uncontrolled Ca++ independent release of neurotransmitters

This answer is incorrect.


This is the effect of α-latrotoxin, the toxin black widows carry.  (See References)

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C) Activation of acetylcholine release at the presynaptic terminals

This answer is incorrect.


Opposite of what happens, We would expect increased acetylcholine release to have some kind of excitatory effect making spasms worse.  (See References)

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D) Complete inhibition of GABA release from presynaptic terminals

This answer is incorrect.


This is the effect of tetanus toxin which results in paralysis and death   (See References)

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References:

1. Vanderah, Todd W., and John Nolte. “Ch. 8: Synaptic Transmission Between Neurons.” Nolte's Essentials of the Human Brain, Elsevier, Philadelphia, PA, 2019.
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anatomy
Dillon MCQ 03
Question ID: 112622039
Question written by dillon. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 11/26/2022
Modified: 11/26/2022
Estimated Permutations: 24

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