Antiepileptic Medications 03

Topic: Pharmacology

Created on Friday, September 28 2007 by jdmiles

Last modified on Friday, September 28 2007.

 
        A) Clonazepam
 
        B) Felbamate
 
        C) Topiramate
 
        D) Valproic acid
 
        E) Gabapentin
 

 

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This question was created on September 28, 2007 by jdmiles.
This question was last modified on September 28, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Clonazepam

This answer is incorrect.

Clonazepam can be used as prophylactic therapy for patients with myoclonic epilepsy, Lennox-Gastaut syndrome, and infantile spasms.  It is not associated with a high risk of aplastic anemia and hepatotoxicity.  (See References)

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B) Felbamate

This answer is correct.

Felbamate is considered effective as adjunctive therapy in the treatment of Lennox-Gastaut syndrome.  However, it is associated with a relatively high risk for hepatotoxicity and aplastic anemia.

  (See References)

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C) Topiramate

This answer is incorrect.

Topiramate is not associated with a high risk of aplastic anemia and hepatotoxicity.

  (See References)

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D) Valproic acid

This answer is incorrect.

Valproic acid is used in the treatment of Lennox-Gastaut syndrome.  It can be associated with hepatotoxicity in young patients.  However, felbamate is more commonly associated wtih hepatotoxicity and aplastic anemia.  (See References)

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E) Gabapentin

This answer is incorrect.

Gabapentin is not associated with a high risk of aplastic anemia and hepatotoxicity.  Gabapentin may be associated with mild CNS side effects.

  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia.
2. Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.
3. Ilo E. Leppik, . . Handbooks in Health Care Company (ISBN:1931981574)	Advertising:
4. French, J., Smith, M., Faught, E., and Brown, L. (1999). "Practice advisory: The use of felbamate in the treatment of patients with intractable epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society." Neurology, 52(8) 1540-5. (PMID:10331676)
5. Trescher, W.H., and Lesser, R.P. (2004). The epilepsies. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, Fourth Edition. Butterworth Heinemann, Philadelphia, pp. 1953-1992.

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pharmacology
Antiepileptic Medications 03
Question ID: 092807072
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 09/28/2007
Modified: 09/28/2007
Estimated Permutations: 163800